Unlocking the body's hidden healing potential
Frequency Therapeutics develops small molecule drugs that activate progenitor cells within the body to restore healthy tissue. Progenitor cells are the natural sources of tissues throughout your body and remain present through adulthood. Through the transitory activation of these progenitor cells, Frequency enables disease modification without the complexity of genetic engineering. Our therapies use proprietary combinations of small-molecule drugs to cause dormant progenitor cells to multiply and create new cells. Our Progenitor Cell Activation (PCA) technology is founded on discoveries in progenitor cell biology by Bob Langer, Sc.D. at MIT and Jeff Karp, Ph.D., at Harvard, with contributions from Xiaolei Yin, Ph.D. and other members of the Karp Lab at Harvard and Brigham & Women's Hospital.
Frequency is leveraging its PCA Regeneration Platform to build a robust pipeline of progenitor cell activators. Because of the broad applicability of the PCA approach, Frequency is currently exploring the potential of PCA across many different therapeutic areas such as hearing loss, skin disorders, muscle regeneration, and gastrointestinal diseases.
Our lead program, FX-322, activates the regrowth of sensory cells in the inner ear to treat chronic noise induced hearing loss, which affects over 48 million people in the U.S. alone, representing a potential $20 billion market with no effective therapeutic solution.
Humans Have Regenerative Abilities—Scientists Just Need to Turn Them On
It's somewhat of a given that over the course of your life, you'll lose your hearing to some degree. But that doesn't necessarily have to be the case. Your intestine can re-create itself every five days or so, and there's a science there that can (hopefully) be applied to other parts of the body. Chris Loose, Co-Founder and Chief Scientific Offer here at Frequency, is a Hertz Foundation Fellow, working amongst a group of fellows and researchers who are looking at regenerative tissue and making it a reality not just for your hearing but perhaps for other parts of the body as well. We could be in for a regenerative future—and perhaps one where we can live to be well over 100 and still look like we're 22.